Solid dispersion melt crystallization (SDMC) concept using binary eutectic system for improvement of dissolution rate

From the designs of product and industrial process perspectives, the solubility of a target material is one of the most valuable qualities. We proposed the 'solid dispersion melt crystallization (SDMC) concept' as a original strategy for dispersing a target material in a matrix one, in which the target material is naturally dispersed between the crevices formed by the matrix material precipitated first. Furthermore, the effects of introducing some operations, such as cooling, agitation and aeration, to the SDMC concept on the dissolution rate were investigated by a binary eutectic system. According to the experimental results, the dissolution rate was enhanced by the operations (cooling, agitation and aeration). This improvement in the dissolution rate was attributed to the SDMC concept-based enhancement of the nucleation rate. Therefore, it was revealed that an increase in the nucleation rate due to the SDMC concept had effectively improved the dissolution rate. (c) 2021 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

Automated summary

The study introduced the original concept of SDMC for dispersing a target material in a matrix, and investigated the effects of cooling, agitation, and aeration on dissolution rate. The experimental results showed that these operations enhanced the dissolution rate by increasing the nucleation rate based on the SDMC concept.