4.6 Article

Design of Broadly Cross-Reactive M Protein-Based Group A Streptococcal Vaccines

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Article Immunology

Cross-reactive immunogenicity of group A streptococcal vaccines designed using a recurrent neural network to identify conserved M protein linear epitopes

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Summary: The study successfully designed a vaccine by predicting linear B-cell epitopes of M types of group A streptococci, which induced cross-reactive antibodies in rabbits against different M types of streptococci, demonstrating potential cross-protection. This research contributes to guiding the future design of broadly protective vaccines against streptococci.

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