Protein Immunization Induces Memory CD4+T Cells That Lack Th Lineage Commitment

functions following secondary challenge with virus. However, the lineage commitment of effector and memory Th cells in vivo following protein vaccination is poorly understood. In this study, we analyzed effector and memory CD4+ T cell differentiation in mice (Mus polarization toward any particular Th cell lineage but had undergone memory differentiation. However, upon challenge with virus, plasticity. In addition, Tfh and memory Tfh cells were generated in response to protein immunization, and these cells differed from but not protein immunization, during either the primary or secondary immune response, restricts the recall of Bcl6 expression and the

Automated summary

This study analyzed effector and memory CD4+ T cell differentiation in mice following protein vaccination, revealing that cells displayed memory differentiation post vaccination. Challenges with virus increased cell plasticity, leading to the generation of Tfh and memory Tfh cells in response to protein immunization.