期刊
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
卷 28, 期 12, 页码 1047-1059出版社
WILEY
DOI: 10.1002/jhbp.1001
关键词
adipokines; adiposity; biliary tract disease; cholangiocarcinoma; obesity
资金
- Faculty of Medicine, Khon Kaen University, Thailand
Obesity is associated with an increased risk of cholangiocarcinoma, although this association may be limited to Western countries. Hormone, cytokine, and metabolite perturbations in obese states have been shown to enhance tumorigenicity and metastasis potentials. Understanding the biological linkage of obesity to cholangiocarcinoma may lead to novel prevention and therapeutic approaches.
Cholangiocarcinoma (CCA) is a malignancy of bile duct epithelium, and its incidence is increasing globally. Numerous factors are reported associated with an increased risk of CCA and vary among populations across different areas. Obesity is a major, worldwide public health problem that leads to several complications and is associated with increased cancer risk. Although several epidemiological studies have shown that obesity is likely associated with the increased risk of CCA, this association might be limited to Western countries. Multiple hormones, cytokines, and metabolite perturbations in obese states have been shown to enhance tumorigenicity and metastasis potentials. Understanding the biological linkage of obesity to CCA might lead to novel prevention and therapeutic approaches to CCA treatment. This review summarizes the current evidence and highlights the knowledge gaps regarding the relationship between obesity and CCA from epidemiological and molecular perspectives.
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