期刊
JOURNAL OF HEMATOLOGY & ONCOLOGY
卷 14, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13045-021-01141-y
关键词
Mesenchymal stem cell; Extracellular vesicle; Exosome; Cancer therapy; Drug delivery
资金
- National Natural Science Foundation of China [81972538]
- China Postdoctoral Science Foundation [2020M683333]
Extracellular vesicles (EVs) are essential regulators of intercellular communication enclosing various biomolecules, and MSC-derived EVs have shown potential applications in cancer treatment. However, challenges remain in translating MSC-derived EVs from bench to bedside.
Extracellular vesicles (EVs) are cell-derived membrane structures enclosing proteins, lipids, RNAs, metabolites, growth factors, and cytokines. EVs have emerged as essential intercellular communication regulators in multiple physiological and pathological processes. Previous studies revealed that mesenchymal stem cells (MSCs) could either support or suppress tumor progression in different cancers by paracrine signaling via MSC-derived EVs. Evidence suggested that MSC-derived EVs could mimic their parental cells, possessing pro-tumor and anti-tumor effects, and inherent tumor tropism. Therefore, MSC-derived EVs can be a cell-free cancer treatment alternative. This review discusses different insights regarding MSC-derived EVs' roles in cancer treatment and summarizes bioengineered MSC-derived EVs' applications as safe and versatile anti-tumor agent delivery platforms. Meanwhile, current hurdles of moving MSC-derived EVs from bench to bedside are also discussed.
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