期刊
JOURNAL OF HAZARDOUS MATERIALS
卷 417, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jhazmat.2021.125963
关键词
Air pollution; L-arginine; Methylation; Mitochondrial DNA; Platelet
资金
- National Key Research and Development Program of China [2017YFC0211600, 2017YFC0211601]
- Beijing Natural Science Foundation [7192098]
- National Natural Science Foundation of China [82073509, 81971416]
- Tianjin Natural Science Foundation [18JCQNJC11700, 18ZXDBSY00190]
- Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, China
Short-term personal exposure to air pollution may result in hypomethylation of platelet mtDNA, but supplementation with L-Arg can mitigate this effect, especially on the D-loop region.
The potential effect of short-term exposure to air pollution on mitochondrial DNA (mtDNA) methylation remains to be explored. This study adopted an experimental exposure protocol nested with an intervention study on Larginine (L-Arg) supplementation among 118 participants. Participants walked along a traffic road for 2 hours in the last day of a 14-day intervention to investigate the effects of short-term personal exposure to air pollution on platelet mtDNA methylation and the possible modifying effects of L-Arg supplementation. Results showed that short-term personal exposure to air pollutants was associated with hypomethylation in platelet mtDNA in 110 participants who completed the study protocol. Specifically, 2-h fine particulate matter (PM2.5) exposure during the outdoor walk was significantly associated with hypomethylation in mt12sRNA; 24-h PM2.5 and black carbon (BC) exposures from the start of the walk till next morning were both significantly associated with hypomethylation in the D-loop region; 24-h BC exposure was also significantly associated with hypomethylation in ATP8_P1. Supplementation with L-Arg could mitigate the air pollution effects on platelet mtDNA methylation, especially the D-loop region. These findings suggest that platelet mtDNA methylation may be sensitive effect biomarker for short-term exposure to air pollution and may help deepen the understanding of the epigenetic mechanisms of adverse cardiovascular effects of air pollution.
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