期刊
JOURNAL OF HAZARDOUS MATERIALS
卷 415, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jhazmat.2021.125663
关键词
Aflatoxin; Fungicide; Synergistic effect; Baicalein; Secondary metabolite
资金
- BioSynergy Research Project of the Ministry of Science, Republic of Korea [NRF-2013M3A9C4078156]
The study found that plant-based compounds such as baicalein can enhance the antifungal effects of strobilurins against aflatoxigenic Aspergillus flavus, transforming them from fungistatic to fungicidal agents. This provides a novel insight for the development of safer and more effective strategies to control aflatoxin contamination.
Aflatoxins are a group of carcinogenic and mutagenic fungal secondary metabolites that have threatened human health and global food security. Aflatoxin contamination can be controlled by applying fungicides, such as strobilurins. Although these compounds have been effective, they may be risky to the environment due to their wide usage. In this study, plant-based compounds were tested to promote the performance of strobilurins (azoxystrobin, pyraclostrobin) against aflatoxigenic Aspergillus flavus; six natural compounds, namely baicalein, nobiletin, meso-dihydroguaiaretic acid, pinoresinol, syringaresinol, and celastrol, were found to exhibit synergistic antifungal effects with strobilurins with fractional inhibitory concentration index < 0.5. Among them, baicalein showed no inhibitory effects on A. flavus when applied alone, but strongly enhanced the in vitro and in situ antifungal and antiaflatoxigenic efficacy of strobilurins and transformed them from fungistatic to fungicidal agents. Therefore, baicalein may be used as an effective natural chemosensitizing agent to improve the performance of strobilurins against A. flavus. The findings of this study provide novel insights for the development of safer and more effective strategies for the control of aflatoxin contamination.
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