期刊
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
卷 36, 期 11, 页码 3077-3083出版社
WILEY
DOI: 10.1111/jgh.15603
关键词
Helicobacter pylori; homocysteine; infection
资金
- Science and Technology Bureau of Taizhou City [1801ky01]
The relationship between H. pylori and serum homocysteine was investigated in a healthy Chinese population. The results showed that H. pylori infection increased the risk of higher homocysteine concentration, especially in cases of persistent infection.
Background and Aim The relationship between the Helicobacter pylori (H. pylori) infection and homocysteine is unclear. We evaluated the effect of H. pylori on serum homocysteine in a healthy Chinese population. Methods A total of 21 184 individuals aged over 18 years underwent C-13/C-14 urease breath test (C-13/C-14-UBT) and blood tests and 5042 individuals with follow-up intervals greater than 6 months. Homocysteine levels are classified according to the Chinese expert consensus. Results The rates of H. pylori infection of normal level, mild level, moderate level, and severe level were 40.9%, 43.8%, 45.8%, and 46.6%, respectively (P = 0.000). H. pylori infection increased the risk of higher homocysteine concentration (OR = 1.406, P = 0.000). In the case-control study, the rates of persistent negative, new infection, persistent infection, and eradication infection were 43.6%, 11.2%, 22.9%, and 22.3%, respectively. The percentage of changes in serum homocysteine levels varied significantly among the different H. pylori infection statuses only in mild level (P = 0.024). Mean changed homocysteine values were higher in the subgroup of persistent infection than in the persistent negative subgroup (P = 0.004) and the eradication infection subgroup (P = 0.034). Serum homocysteine values were elevated only in the subgroup with over 3 years interval time and persistent infection (n = 107, mean paired differences = 1.1 +/- 4.6 mu mol/L, P = 0.014). Conclusions There is a relationship between H. pylori and serum homocysteine, and persistent infection leads to elevation of the latter.
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