期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 218, 期 8, 页码 -出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20202579
关键词
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资金
- National Institutes of Health [NCI CA224175, CA210240, CA232093, CA163117, CA207983, CA163120, CA218513, K00 CA212451]
- NIAID [AI144301]
- Malcolm HewittWeiner Foundation
- Hartwell Foundation
- Manning Foundation
- Thompson Family Foundation
- Sohn Foundation
- AHEPA Fifth District Cancer Research Foundation
- Pediatric Oncology Experimental Therapeutics Investigator's Consortium
- Breast Cancer Research Foundation
- Daedalus Fund
- Children's Cancer and Blood Foundation
- Clinical and Translational Science Center
- Swiss National Science Foundation [P2SKP3 174785, P400PB 186791]
- Mary K. Ash Charitable Foundation
- EPFL-WISH Foundation
- Swiss National Science Foundation (SNF) [P400PB_186791, P2SKP3_174785] Funding Source: Swiss National Science Foundation (SNF)
EVPs play a crucial role in immune homeostasis and pathophysiology, regulating immune responses and impacting disease progression.
Intercellular communication among immune cells is vital for the coordination of proper immune responses. Extracellular vesicles and particles (EVPs) act as messengers in intercellular communication, with important consequences for target cell and organ physiology in both health and disease. Under normal physiological conditions, immune cell-derived EVPs participate in immune responses by regulating innate and adaptive immune responses. EVPs play a major role in antigen presentation and immune activation. On the other hand, immune cell-derived EVPs exert immunosuppressive and regulatory effects. Consequently, EVPs may contribute to pathological conditions, such as autoimmune and inflammatory diseases, graft rejection, and cancer progression and metastasis. Here, we provide an overview of the role of EVPs in immune homeostasis and pathophysiology, with a particular focus on their contribution to innate and adaptive immunity and their potential use for immunotherapies.
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