4.7 Article

Long non-coding RNA SLC2A1-AS1 induced by GLI3 promotes aerobic glycolysis and progression in esophageal squamous cell carcinoma by sponging miR-378a-3p to enhance Glut1 expression

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Summary: The study revealed that lncRNA SLC2A1-AS1 is significantly over-expressed in lung adenocarcinoma (LUAD) and is closely correlated with patients' overall survival, acting as an oncogene to promote cancer cell proliferation. Additionally, the transcription factor TFAP2A can directly bind to the promoter region of SLC2A1-AS1 gene and positively regulate its transcription, further promoting cell proliferation in lung squamous cell carcinoma and pancreatic adenocarcinoma.

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