4.7 Article

Empty spiracles homeobox genes EMX1 and EMX2 regulate WNT pathway activation in sarcomagenesis

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Summary: EMX1 and EMX2 genes act as tumor suppressors in sarcomas by repressing the activity of stem cell regulatory genes, thus inhibiting cell malignancy and stemness. Their downregulation leads to more aggressive tumors with higher stem cell gene expression, suggesting a generalized behavior in regulating proliferation of neural crest-derived progenitors.

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