Efficacy and Side Effects of Low Single Doses of Cloprostenol Sodium or Dinoprost Tromethamine to Induce Luteolysis in Donkeys

Due to the limited literature available evaluating doses of Prostaglandin F2 alpha in donkeys, doses for horses have been extrapolated and used as guidelines. This study aimed to assess the efficacy and side effects of four different cloprostenol sodium and dinoprost tromethamine doses to induce luteolysis in jennies. Sixty-three cycles of seven Jennies (nine cycles per jenny) were used in this study. Seven days after ovulation, jennies randomly received one of the treatments in a crossover design as follows: Control, no treatment was administered; C1, 250 mu g of cloprostenol sodium (CS, Estrumate , Merck Animal Health, USA); C2, 125 mu g of CS; C3, 65.5 mu g of CS, C4, 37.5 mu g of CS; DT1, 5 mg of dinoprost tromethamine (DT, Lutalyse, Zoetis, USA); DT2, 2.5 mg of DT; DT3, 1.25 mg of DT; DT4, 0.625 mg of DT. Jennies were monitored for 30 minutes following treatment, and adverse effects were recorded. The measurement of the corpus luteum (CL) and the length of the estrous cycle were recorded. All DT and CS treatment doses were effective (P < .0001) in reducing the estrous cycle length compared to jenny's Control cycle. The CL volume was decreased in all treated groups one day after treatment (P < .05). The adverse effects were reduced as the dose of both Prostaglandin F2 alpha analogs were reduced. In conclusion, a single low dose of dinoprost tromethamine (0.625 mg) or cloprostenol sodium (37.5 mu g) can induce luteolysis and shorten the estrous length in jennies producing fewer adverse effects. Published by Elsevier Inc.

Automated summary

This study evaluated the efficacy and side effects of different doses of cloprostenol sodium and dinoprost tromethamine in inducing luteolysis in jennies. Results showed that low doses of both drugs were effective in reducing the length of the estrous cycle with fewer adverse effects.