期刊
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
卷 900, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jelechem.2021.115674
关键词
Zinc Manganese Oxide; Hydrogen peroxide; Free radicals; In-vitro assay; Cellular assay
A ZnMn2O4-based H2O2 sensor has been proposed, showing excellent electrochemical activity and promising applications.
Hydrogen peroxide (H2O2) is a renowned industrial oxidant that plays a significant role in cell biology, and pathogenesis. On this note, we propose a simple Zinc Manganese Oxide (ZnMn2O4; ZMO) based H2O2 sensor for rapid in-situ tracking and determination of H2O2 from live cells, and bio-samples. The ZMO catalyst have been synthesized via simple scalable protocol; surface morphology, elemental composition, electronic states, crystallinity, and other physiochemical properties are studied and discussed in-detail using various spectroscopic tools. The ZMO modified electrode displays an excellent electrochemical activity toward H2O2 sensing with a wide dynamic range (20 nM-10 mM), low detection limit (8.3 nM), excellent selectivity, reproducibility, operational stability, and rapid response time (<3 s). Further, the ZMO modified electrode have been found successful at in-vivo real-time tracking of H2O2 released from live HeLa cells, and in-vitro analysis of H2O2 spiked in water, tooth paste, and human serum samples.
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