4.6 Article

Evaluation of resveratrol-doped adhesive with advanced dentin bond durability

期刊

JOURNAL OF DENTISTRY
卷 114, 期 -, 页码 -

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.jdent.2021.103817

关键词

Dental adhesive; Dentin bonding; Bond durability; Resveratrol; Biofilm

资金

  1. National Natural Science Foundation of China [81771112, 81901043, 81970918]
  2. Youth Clinical Research Fund of Chinese Stomatological Association [CSA-B2018-01]

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The study demonstrated that resveratrol-doped adhesive significantly improved the durability of dentin bonding and secondary caries management. Additionally, the resveratrol-doped adhesive exhibited antibiofilm properties and acceptable biocompatibility. Therefore, the application of resveratrol-doped adhesive holds promise for increasing the lifetime of composite restorations.
Objectives: This paper aimed to evaluate the influence of resveratrol-doped adhesive on the durability and antibiofilm capability of dentin bonding. Methods: Experimental adhesives were prepared by incorporating resveratrol into a universal adhesive at concentrations of 0 (control), 0.1, 1, and 10 mg/mL. The microtensile bond strength, fracture modes, and adhesive-dentin interface nanoleakage were assessed after 24 h of water storage, 10,000 times of thermocycling or 1month of collagenase ageing. Relevant antibiofilm capability on Streptococcus mutans (S. mutans), in situ zymography, degree of conversion, and cytotoxicity of resveratrol-doped adhesives were also determined. Results: Irrespective of thermocycled or collagenase ageing, the resveratrol-doped adhesive (1 mg/mL) maintained the bond strength and reduced the nanoleakage expression. Meanwhile, the inhibitory ability on endogenous protease activity and S. mutans biofilm formation with acceptable biocompatibility were obtained. Conclusions: This study suggested that the resveratrol-doped adhesive achieved effective improvement on dentin bond durability and secondary caries management. Clinical significance: The application of the resveratrol-doped adhesive indicates promising benefits to increase the lifetime of composite restorations.

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