期刊
JOURNAL OF CONTROLLED RELEASE
卷 335, 期 -, 页码 541-556出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2021.06.003
关键词
Magnetic nanoparticles; Magnetic hydrogel; Stimuli-responsiveness; Biomedical applications
资金
- National Natural Science Foundation of China [31870997, 81770091]
- National Key R&D Program of China [2020YFA0112600]
- Shanghai Municipal Education Commission Innovative Program [2017-01-07-00-07-E00038]
- Fundamental Research Funds for the Central Universities
- Shanghai Science and Technology Committee [20dz1101200]
- Shanghai Pulmonary Hospital Innovation Program [FKCX1906]
Magnetic-responsive hydrogels, prepared by embedding magnetic nanomaterials into hydrogel networks, have advantages such as rapid magnetic response, precise control, and non-invasively remote operation for biomedical applications. This review summarizes the synthetic methods, roles in different applications, and future perspectives of magnetic hydrogels.
Smart hydrogels which can respond to external stimuli have been widely focused with increasing interest. Thereinto, magnetic-responsive hydrogels that are prepared by embedding magnetic nanomaterials into hydrogel networks are more advantageous in biomedical applications due to their rapid magnetic response, precisely temporal and spatial control and non-invasively remote actuation. Upon the application of an external magnetic field, magnetic hydrogels can be actuated to perform multiple response modes such as locomotion, deformation and thermogenesis for therapeutic purposes without the limit of tissue penetration depth. This review summarizes the latest advances of magnetic-responsive hydrogels with focus on biomedical applications. The synthetic methods of magnetic hydrogels are firstly introduced. Then, the roles of different response modes of magnetic hydrogels played in different biomedical applications are emphatically discussed in detail. In the end, the current limitations and future perspectives for magnetic hydrogels are given.
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