Early Laboratory Diagnosis of COVID-19 by Antigen Detection in Blood Samples of the SARS-CoV-2 Nucleocapsid Protein

Letter Virology

A word of caution in interpreting COVID-19 diagnostics tests

Severino Jefferson Ribeiro da Silva et al.

JOURNAL OF MEDICAL VIROLOGY (2021)

Article Infectious Diseases

Detection of SARS-CoV-2 N-antigen in blood during acute COVID-19 provides a sensitive new marker and new testing alternatives

Quentin Le Hingrat et al.

Summary: The evaluation of SARS-CoV-2 nucleocapsid antigen (N-antigen) ELISA detection in serum or plasma using the COVID-19 Quantigene (R) showed high specificity and sensitivity within the first 14 days after symptom onset, offering a valuable new option for COVID-19 diagnosis.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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Review Public, Environmental & Occupational Health

Nosocomial transmission and outbreaks of coronavirus disease 2019: the need to protect both patients and healthcare workers

Mohamed Abbas et al.

Summary: The COVID-19 pandemic has significantly impacted hospitals and healthcare providers worldwide, increasing the risk of nosocomial transmission and outbreaks to non-COVID patients or residents, who are at the highest risk of mortality. Reports on nosocomial outbreaks of SARS-CoV-2 have shown variable attack rates of up to 60%, with high mortality. There is limited evidence on transmission dynamics and the role of healthcare workers in initiating or amplifying nosocomial outbreaks, but there has been a shift towards expanded testing criteria for patients and healthcare workers, including asymptomatic individuals, which appears crucial in identifying and controlling outbreaks.

ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL (2021)

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Review Microbiology

Performance of Saliva, Oropharyngeal Swabs, and Nasal Swabs for SARS-CoV-2 Molecular Detection: a Systematic Review and Meta-analysis

Rose A. Lee et al.

Summary: Nasopharyngeal (NP) swabs are considered the best sample for diagnosing SARS-CoV-2, but saliva, oropharyngeal (OP), nasal (NS) swabs, and combinations of OP/NS are promising alternatives. While some alternative samples had lower detection rates, a combination of OP/NS showed comparable performance to NP swabs. The absence of RNA extraction (saliva) and use of a more sensitive nucleic acid amplification test (NS) significantly reduced the positive yield of alternative samples.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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Editorial Material Medicine, General & Internal