Down-regulation of hsa_circ_0006470 predicts tumor invasion: A new biomarker of gastric cancer

Background Gastric cancer (GC) is a common cancer. Circular RNAs (circRNAs) regulate the pathogenesis of GC. This study aims to explore its potential as a GC biomarker. Methods The expression of hsa_circ_0006470 in GC tissues and GC cell lines was measured by quantitative reverse transcription-polymerase chain reaction. The diagnostic value of hsa_circ_0006470 was estimated by the receiver operating characteristic (ROC) curve. Results Compared with adjacent normal tissues, the expression of hsa_circ_0006470 in GC tissues was significantly lower. The expression levels of hsa_circ_0006470 in different TNM stages and different invasion degrees were significantly different. The area under the ROC curve was 0.783, with sensitivity and specificity 0.725 and 0.750, respectively. Conclusions Hsa_circ_0006470 has a high value as a diagnostic biomarker for GC.

Automated summary

This study found that the circular RNA hsa_circ_0006470 is significantly downregulated in gastric cancer tissues and has the potential to be a diagnostic biomarker for gastric cancer, with high specificity and sensitivity.