期刊
JOURNAL OF CLINICAL LABORATORY ANALYSIS
卷 35, 期 7, 页码 -出版社
WILEY
DOI: 10.1002/jcla.23863
关键词
acute pancreatitis; cell population data; prediction; scoring system; severity
资金
- National Natural Science Foundation Youth Project of China [81601665]
- National Natural Science Foundation of China [81600501]
This study explored the use of leukocyte cell population data (CPD) as an indicator for early prediction of severe acute pancreatitis (SAP). Through extensive analysis, four CPD parameters were identified as having the potential to play a crucial role in the early diagnosis of SAP, with a high sensitivity, specificity, and diagnostic accuracy. The study suggests that these CPD parameters could be integrated into a predictive system marker for severity of acute pancreatitis.
Background The prediction for severe acute pancreatitis (SAP) is the key to give timely targeted treatment. Leukocyte cell population data (CPD) have been widely applied in early prediction and diagnosis of many diseases, but their predictive ability for SAP remains unexplored. We aim to testify whether CPD could be an indicator of AP severity in the early stage of the disease. Methods The prospective observational study was conducted in the emergency department ward of a territory hospital in Shanghai. The enrolled AP patients should meet 2012 Atlanta guideline. Results Totally, 103 AP patients and 62 healthy controls were enrolled and patients were classified into mild AP (n = 30), moderate SAP (n = 42), and SAP (n = 31). Forty-two CPD parameters were examined in first 3 days of admission. Four CPD parameters were highest in SAP on admission and were constantly different among 3 groups during first 3 days of hospital stay. Eighteen CPD parameters were found correlated with the occurrence of SAP. Stepwise multivariate logistic regression analysis identified a scoring system of 4 parameters (SD_LALS_NE, MN_LALS_LY, SD_LMALS_MO, and SD_AL2_MO) with a sensitivity of 96.8%, specificity of 65.3%, and AUC of 0.87 for diagnostic accuracy on early identification of SAP. AUC of this scoring system was comparable with MCTSI, SOFA, APACHE II, MMS, BISAP, or biomarkers as CRP, PCT, and WBC in prediction of SAP and ICU transfer or death. Conclusions Several leukocyte CPD parameters have been identified different among MAP, MSAP, and SAP. They might be ultimately incorporated into a predictive system marker for severity of AP.
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