期刊
JOURNAL OF CLINICAL EPIDEMIOLOGY
卷 137, 期 -, 页码 250-261出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jclinepi.2021.05.008
关键词
Multicenter clinical trials (MCT); Randomized controlled trials (RCTs); CONSORT guideline; Extension; Reporting quality; Heterogeneity
资金
- EQUATOR China Centre Funding OF Famous Horse Charity Foundation
- National Natural Science Foundation of China [81704198]
This study evaluated the reporting quality of multicenter RCTs and found that although CONSORT has improved reporting quality, specific reporting for multicenter characteristics remains weak, highlighting the need for a CONSORT extension for multicenter trials.
Objective: To assess the reporting quality of randomized controlled trials (RCTs) with multicenter design, particularly whether necessary information related to multicenter characteristics was adequately reported. Study Design and Setting: Through a search of 4 international electronic databases, we identified multicenter RCTs published in English from 1975 to 2019. Reporting quality was assessed by the CONSORT (Consolidated Standards of Reporting Trials) checklist (37 items) and by a self-designed multicenter-specific checklist (27 items covering multicenter design, implement and analysis). The scores of trials published in three time periods (1975-1995; 1996-2009; and 2010-2019) were also compared. Results: A total of 2,844 multicenter RCTs were included. For the CONSORT checklist, the mean (standard deviation) re-porting score was 24.1 (5.5), 12 items were assessed as excellent (> 90%), 12 items as good (50%-90%), and 13 items as poor (< 50%). For the multicenter checklist, the reporting score was 3.9 (2.2), only 3 items were excellent or good, and the remaining 24 items were poor. Time period comparison showed that reporting quality improved over time, especially after the CONSORT 2010 issued. Conclusion: Although CONSORT appears to have enhanced the reporting quality of multicenter RCTs, further improvement is needed. A CONSORT extension for multicenter trials should be developed. (C) 2021 The Authors. Published by Elsevier Inc.
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