期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 107, 期 1, 页码 E293-E302出版社
ENDOCRINE SOC
DOI: 10.1210/clinem/dgab589
关键词
type 1 diabetes; HLA genotypes; partial remission
资金
- National Key Technology Research and Development Program of China [2018YFC1315600, 2017YFC1309604]
- science and technology innovation Program of Hunan Province [2020RC4044]
- Natural Science Foundation of Hunan Province, China [2019JJ40419]
- Science and Technology Major Project of Hunan Province [2017SK1020]
This study aimed to investigate the association between PR status and HLA genotypes in patients with T1D. The results showed that patients carrying susceptible HLA genotypes were less prone to undergo PR, and the recovery extent of beta-cell function during the PR phase was lower in adults.
Context Partial remission (PR) is a specific stage in type 1 diabetes (T1D). Although human leukocyte antigen (HLA) class II loci are the strongest genetic determinants in T1D, the relationship between PR and HLA remains unclear. Objective To investigate the association between PR status and HLA genotypes in patients with T1D. Methods A total of 237 patients with T1D were included. PR was defined according to C-peptide >= 300 pmol/L. The frequency of PR and peak C-peptide levels during remission phase were compared according to HLA status. Clinical characteristics including age of onset and diabetes autoantibodies were collected. All analyses were duplicated when subjects were divided into childhood- and adult-onset T1D. Results The median follow-up time was 24 months, 65.8% (156/237) of patients with T1D went into PR. DR9/DR9 carriers had a lower PR rate (44.2% vs 70.6%, P = .001) and were less likely to enter PR (OR = 0.218, 95% CI 0.098-0.487, P < .001) than the non-DR9/DR9 carriers, observed in both childhood- and adult-onset T1D. Besides, the peak C-peptide level during PR phase was also lower in DR9/DR9 carriers, and more notable in adult-onset T1D. When compared with non-DR9/DR9 carriers, T1D with DR9/DR9 genotype presented an older age of onset and a lower positivity of zinc transporter 8 antibody (ZnT8A), and the lower trend of ZnT8A was only found in adult-onset T1D (P = .049). Conclusion Patients with T1D carrying susceptible DR9/DR9 are less prone to undergo PR. Additionally, the recovery extent of beta-cell function during the PR phase tends to be lower in adults carrying DR9/DR9, which might be associated with ZnT8A.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据