4.6 Article

Stereoselective separation of sulfoxaflor by electrokinetic chromatography and applications to stability and ecotoxicological studies

期刊

JOURNAL OF CHROMATOGRAPHY A
卷 1654, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.chroma.2021.462450

关键词

Electrokinetic chromatography; Chiral separation; Sulfoxaflor; Ecotoxicity; Non-target aquatic organisms

资金

  1. Spanish Ministry of Science and Innovation [PID2019-104913GB-I00]
  2. University of Alcalafor [CCG19/CC-068, CCG20/CC-023]
  3. Direccion General de Universidades e Investigacion de la Comunidad de Madrid (Spain), REMTAVARES project [S2018/EMT-4341]
  4. ICTS NANBIOSIS, Confocal Microscopy Service: Ciber in Bioengineering, Biomaterials & Nanomedicine (CIBER-BNN) at the University of Alcala(CAI Medicine Biology)
  5. Ministry of Science, Innovation and Universities [FPU18/00787]

向作者/读者索取更多资源

An Electrokinetic Chromatography method was developed for the stereoselective analysis of sulfoxaflor, achieving baseline separation of its four stereoisomers. The method showed good performance for commercial agrochemical analysis and sulfoxaflor toxicity prediction.
An Electrokinetic Chromatography method was developed for the stereoselective analysis of sulfoxaflor, a novel sulfoximine agrochemical with two chiral centers. A screening with fourteen negatively charged CDs was performed and Succinyl-beta-CD (Succ-beta-CD) was selected. A 15 mM concentration of this CD in a 100 mM borate buffer (pH 9.0), using an applied voltage of 20 kV and a temperature of 15 degrees C made possible the baseline separation of the four stereoisomers of sulfoxaflor in 13.8 min. The evaluation of the linearity, accuracy, precision, LODs and LOQs of the method developed showed its performance to be applied to the analysis of commercial agrochemical formulations, the evaluation of the stability of sulfoxaflor stereoisomers under biotic and abiotic conditions, and to predict, for the first time, sulfoxaflor toxicity (using real concentrations instead of nominal concentrations), on two non-target aquatic organisms, the freshwater plant, Spirodela polyrhiza, and the marine bacterium, Vibrio fischeri. (C) 2021 The Authors. Published by Elsevier B.V.

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