Metal-organic framework grafted with melamine for the selective recognition and miniaturized solid phase extraction of aristolochic acid I from traditional Chinese medicine

Aristolochic acid I is a nephrotoxic compound and exist in some traditional Chinese medicines at trace level. Up to now, specific enrichment of aristolochic acid I remains important procedure and key problem in its analysis. In this study, melamine was proposed as the recognition unit and grafted on the surface of metal-organic framework to fabricate a specific material for aristolochic acid I . This material was prepared by using a two-step strategy and the preparation process was optimized. The physical and chemical properties were investigated using scanning electron microscopy, Fourier-transfer infrared spectroscopy, X-ray diffraction and nitrogen adsorption-desorption techniques. Adsorption properties were evaluated by binding experiments. The melamine modified material exhibited a uniform morphology, high spe-cific surface area (460.20 m(2) g(-1)), high adsorption capacity (25.57 mg g(-1)), fast mass transfer rate and excellent selectivity. Further, a specific and sensitive method was established by using this material as adsorbent of mini-solid phase extraction. The limit of detection was as low as 0.02 mu g mL(-1). Therefore, melamine modified metal-organic framework is an ideal adsorbent for the recognition and enrichment of aristolochic acid I. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

The melamine modified metal-organic framework showed uniform morphology, high specific surface area, high adsorption capacity, fast mass transfer rate, and excellent selectivity, making it an ideal adsorbent for recognition and enrichment of aristolochic acid I. Additionally, a specific and sensitive method for mini-solid phase extraction was successfully established using this material, achieving a low limit of detection of 0.02 μg mL⁻¹.