期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1651, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.chroma.2021.462338
关键词
beta-cyclodextrin; Anhydride; Chiral stationary phases; Enantiomers; Chiral separation
资金
- National Natural Science Foundation of China [21822407, 21974146]
- Foundation for Science and Tech Research Project of Gansu Province [20JR10RA052, 20JR5RA573]
- Natural Science Foundation of Zhejiang Province [LZY21E030001]
In this study, a series of excellent chiral stationary phases were developed using anhydride modified beta-cyclodextrin for enantioseparation, demonstrating good resolution and repeatability. These new CSPs show great potential for chiral separation in actual applications.
beta-Cyclodextrin can be functionalized by derivation of reactive hydroxyl on the ring due to its special chiral environment and structural characteristics, which can be used to identify or separate a variety of chiral substance. In this manuscript, a series of excellent chiral stationary phases for high-performance liquid chromatography were developed for enantioseparation by using anhydride modified beta-cyclodextrin bearing chiral (R/S)-alpha-phenethylamine or (S)-(+)-2-amino-1-propanol. They were characterized by elemental analysis, Fourier transform infrared spectra (FT-IR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and BET. These chiral stationary phases presented good resolution and repeatability, about 17 kinds of enantiomers were effectively separated. And most of enantiomers were separated better than those reported in the literature in the same both normal and reversed phase modes. The RSD values of R-s for repeatability and column-to-column were below 0.44% and 2.83%, respectively. All results revealed that these new CSPs show great prospect for chiral separation in actual applications. (C) 2021 Elsevier B.V. All rights reserved.
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