期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1653, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.chroma.2021.462406
关键词
Chiralpak IA-3; Green chiral separation; Paroxetine; Enantiomers; Diastereomers; Reversed-phase HPLC
A simple and green high-performance liquid chromatography method has been developed for the separation of paroxetine from its enantiomeric and diastereomeric impurities, allowing baseline separation without interference from other chiral and achiral impurities.
A simple and green high-performance liquid chromatography method for the separation of paroxetine from its enantiomeric and diastereomeric impurities has been developed. The simultaneous chromatographic resolution was carried out on the amylose-based Chiralpak IA-3 chiral stationary phase using the mixture ethanol-water-diethylamine 80:20:0.1 (v/v/v) as a mobile phase. The effects of substitution of ethanol with methanol or acetonitrile and changes in column temperature on selectivity have been carefully investigated. The optimized single-run HPLC protocol allows the baseline separation of the enantiomers of paroxetine without suffering from interference from five other chiral and achiral impurities reported in the monograph of the European Pharmacopoeia. (c) 2021 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据