期刊
JOURNAL OF CHEMICAL THERMODYNAMICS
卷 159, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jct.2021.106474
关键词
Alogliptin Benzoate; Pure solvents; Solubility Correlation; Single crystal; Thermodynamic properties
The solubility of Alogliptin Benzoate in different solvents increases with temperature, and the fitting results of four thermodynamic models correlate well with the experimental solubility. The dissolution of Alogliptin Benzoate form A is found to be exothermic and spontaneous, and its single structure is analyzed.
The solubility of Alogliptin Benzoate (AB) in eight pure solvents (water, methanol, ethanol, n-propanol, isopropanol, acetone, acetonitrile, N, N-dimethylformamide (DMF)) was measured from 278.15 K to 318.15 K at atmospheric pressure by the laser monitoring method. An increasing trend with the temperature was shown for the solubility. The fitting results of each model correlated well for the experimental solubility using four thermodynamic models. The thermodynamic properties of Alogliptin Benzoate form A were evaluated, which show the dissolutions of AB to be exothermic and spontaneous. The single structure of form A of AB was also analysed. (c) 2021 Elsevier Ltd.
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