4.7 Article

Delineating the Ligand-Receptor Interactions That Lead to Biased Signaling at the μ-Opioid Receptor

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Structure of the neurotensin receptor 1 in complex with β-arrestin 1

Weijiao Huang et al.

NATURE (2020)

Article Multidisciplinary Sciences

Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc

Dean P. Staus et al.

NATURE (2020)

Review Pharmacology & Pharmacy

Critical Assessment of G Protein-Biased Agonism at the μ-Opioid Receptor

Alexander Gillis et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2020)

Review Pharmacology & Pharmacy

A Biased View of μ-Opioid Receptors?

Alexandra E. Conibear et al.

MOLECULAR PHARMACOLOGY (2019)

Article Multidisciplinary Sciences

Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs

Scott A. Hollingsworth et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs

John D. McCorvy et al.

NATURE CHEMICAL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

GPCRdb in 2018: adding GPCR structure models and ligands

Gaspar Pandy-Szekeres et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Pharmacology & Pharmacy

The novel mu-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception

Rob Hill et al.

BRITISH JOURNAL OF PHARMACOLOGY (2018)

Article Multidisciplinary Sciences

Structure of the μ-opioid receptor-Gi protein complex

Antoine Koehl et al.

NATURE (2018)

Article Medicine, General & Internal

The Role of Science in Addressing the Opioid Crisis

Nora D. Volkow et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Biochemistry & Molecular Biology

Understanding the GPCR biased signaling through G protein and arrestin complex structures

X. Edward Zhou et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics

Cullen L. Schmid et al.

Article Multidisciplinary Sciences

Structure-based discovery of opioid analgesics with reduced side effects

Aashish Manglik et al.

NATURE (2016)

Article Pharmacology & Pharmacy

Recent updates on GPCR biased agonism

Andre S. Pupo et al.

PHARMACOLOGICAL RESEARCH (2016)

Article Multidisciplinary Sciences

The role of kinetic context in apparent biased agonism at GPCRs

Carmen Klein Herenbrink et al.

NATURE COMMUNICATIONS (2016)

Article Chemistry, Physical

Long-Time-Step Molecular Dynamics through Hydrogen Mass Repartitioning

Chad W. Hopkins et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2015)

Article Multidisciplinary Sciences

Structural insights into μ-opioid receptor activation

Weijiao Huang et al.

NATURE (2015)

Article Cell Biology

Recent developments in biased agonism

James W. Wisler et al.

CURRENT OPINION IN CELL BIOLOGY (2014)

Article Pharmacology & Pharmacy

First Clinical Experience With TRV130: Pharmacokinetics and Pharmacodynamics in Healthy Volunteers

David G. Soergel et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2014)

Article Multidisciplinary Sciences

Molecular control of δ-opioid receptor signalling

Gustavo Fenalti et al.

NATURE (2014)

Review Biochemistry & Molecular Biology

Emerging structural insights into biased GPCR signaling

Arun K. Shukla et al.

TRENDS IN BIOCHEMICAL SCIENCES (2014)

Review Pharmacology & Pharmacy

Biased ligands at G-protein-coupled receptors: promise and progress

Jonathan D. Violin et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2014)

Article Biochemistry & Molecular Biology

The Dynamic Process of β2-Adrenergic Receptor Activation

Rie Nygaard et al.

Article Chemistry, Physical

PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data

Daniel R. Roe et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2013)

Article Chemistry, Physical

Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 2. Explicit Solvent Particle Mesh Ewald

Romelia Salomon-Ferrer et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2013)

Article Multidisciplinary Sciences

Co-Expression of GRK2 Reveals a Novel Conformational State of the μ-Opioid Receptor

Sarah A. Nickolls et al.

PLOS ONE (2013)

Article Pharmacology & Pharmacy

A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphines

Scott M. DeWire et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)

Review Pharmacology & Pharmacy

Non-Analgesic Effects of Opioids: Opioid-induced Respiratory Depression

Merel Boom et al.

CURRENT PHARMACEUTICAL DESIGN (2012)

Article Chemistry, Medicinal

Automation of the CHARMM General Force Field (CGenFF) II: Assignment of Bonded Parameters and Partial Atomic Charges

K. Vanommeslaeghe et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)

Article Chemistry, Medicinal

Automation of the CHARMM General Force Field (CGenFF) I: Bond Perception and Atom Typing

K. Vanommeslaeghe et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)

Article Multidisciplinary Sciences

Structure of the δ-opioid receptor bound to naltrindole

Sebastien Granier et al.

NATURE (2012)

Article Multidisciplinary Sciences

Structure of the human κ-opioid receptor in complex with JDTic

Huixian Wu et al.

NATURE (2012)

Article Multidisciplinary Sciences

Crystal structure of the μ-opioid receptor bound to a morphinan antagonist

Aashish Manglik et al.

NATURE (2012)

Article Multidisciplinary Sciences

Crystal structure of the β2 adrenergic receptor-Gs protein complex

Soren G. F. Rasmussen et al.

NATURE (2011)

Article Multidisciplinary Sciences

Activation mechanism of the β2-adrenergic receptor

Ron O. Dror et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Chemistry, Multidisciplinary

CHARMM General Force Field: A Force Field for Drug-Like Molecules Compatible with the CHARMM All-Atom Additive Biological Force Fields

K. Vanommeslaeghe et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2010)

Article Chemistry, Physical

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

Jeffery B. Klauda et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2010)

Article Biochemical Research Methods

OPM: Orientations of proteins in membranes database

MA Lomize et al.

BIOINFORMATICS (2006)

Article Biochemistry & Molecular Biology

β-arrestin-dependent, G protein-independent ERK1/2 activation by the β2 adrenergic receptor

SK Shenoy et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Pharmacology & Pharmacy

Morphine side effects in beta-arrestin 2 knockout mice

KM Raehal et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)