期刊
JOURNAL OF CHEMICAL INFORMATION AND MODELING
卷 61, 期 6, 页码 2780-2787出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jcim.1c00198
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- University of Brescia
Orf7a in SARS-CoV-2 structurally resembles members of the immunoglobulin superfamily and ICAMs, potentially contributing to virus infectivity and pathogenicity by forming a complex with LFA-1. The study utilized protein-protein docking, MD simulations, and MM-GBSA to provide refined models for insight into this macromolecular assembly.
In the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) genome, open reading frames (ORFs) encode for viral accessory proteins. Among these, Orf7a structurally resembles the members of the immunoglobulin (Ig) superfamily and intracellular adhesion molecules (ICAMs), in particular. ICAMs are involved in integrin binding through lymphocyte function-associated antigen 1 (LFA-1). Based on such considerations and on previous findings on SARS-CoV, it has been postulated that the formation of the LFA-1/Orf7a complex could contribute to SARS-CoV-2 infectivity and pathogenicity. With the current work, we aim at providing insight into this macromolecular assembly, taking advantage of the recently reported SARS-CoV-2 Orf7a structure. Protein-protein docking, molecular dynamics (MD) simulations, and a Molecular Mechanical-Generalized Born Surface Area (MM-GBSA)-based stage were enrolled to provide refined models.
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