期刊
JOURNAL OF CHEMICAL EDUCATION
卷 98, 期 8, 页码 2675-2686出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jchemed.0c01231
关键词
Upper-Division Undergraduate; Undergraduate Research; Analytical Chemistry; Qualitative Analysis; Forensic Chemistry; Hands-On Learning/Manipulatives; Laboratory Equipment/Apparatus; Drugs/Pharmaceuticals; IR Spectroscopy; Chemometrics
资金
- Aznar Rodriguez-Monteverde [PEJ16/IND/TL-1880]
- Instituto Universitario de Investigacion en Ciencias Policiales (IUICP) from the University of Alcala [IUICP/2019/06, IUICP/2019/07]
- Spanish National Youth Guarantee System
- European Social Fund [PEJ2018003933-A]
Infrared (IR) spectroscopy is a widely used technique in chemical, pharmaceutical, and forensic sciences, but some graduate students lack training in optimizing experimental parameters and chemical substance identification. This laboratory practice introduces students to the basics of IR instrumental conditions and chemometrics analysis through visual spectra comparison and statistical analysis.
Infrared (IR) spectroscopy is a vibrational spectroscopic technique useful in chemical, pharmaceutical, and forensic sciences. It is essential to identify chemicals for reasons spanning from scientific research and academic practices to quality control in companies. However, in some university degrees, graduate students do not get the proficiency to optimize the experimental parameters to obtain the best IR spectra; to correlate the IR spectral bands with the molecular vibrations (chemical elucidation); to have some criteria for any substance identification (especially relevant in quality control to recognize counterfeit); and to apply chemometrics for comparing, visualizing, and classifying the IR spectra. This work presents an experimental laboratory practice for an introductory teaching of the IR instrumental conditions in the identification of substances based on visual spectra comparison and statistical analysis and matching. Then, the selected IR conditions are applied to different commercial drugs, in the solid state or in solution, mostly composed of acetaminophen. Finally, the students apply chemometrics analysis to the IR data. This practice was designed for the training in a chemistry subject for undergraduate students of the chemistry, pharmacy, or forensics degrees, among others related to science, medical, food, or technological sciences.
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