期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 41, 期 12, 页码 3378-3390出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X211039597
关键词
Brain tumors; dual-echo; dynamic susceptibility contrast (DSC); perfusion; permeability
资金
- Arizona Biomedical Research Commission [ADHS16-162414]
- NIH/NCI [R01 CA213158, CA158079]
- Foundation of the ASNR Comparative Effectiveness Grant
- NIH [NS082609, CA220378, CA221938]
- Philips Healthcare
By comparing dual-echo acquisitions with standard double-dose single-echo acquisitions, the study shows similar rCBV results, suggesting a potential reduction in contrast agent dose with significant pulse sequence flexibility and complementary tumor perfusion and permeability metrics.
Relative cerebral blood volume (rCBV) obtained from dynamic susceptibility contrast (DSC) MRI is adversely impacted by contrast agent leakage in brain tumors. Using simulations, we previously demonstrated that multi-echo DSC-MRI protocols provide improvements in contrast agent dosing, pulse sequence flexibility, and rCBV accuracy. The purpose of this study is to assess the in-vivo performance of dual-echo acquisitions in patients with brain tumors (n = 59). To verify pulse sequence flexibility, four single-dose dual-echo acquisitions were tested with variations in contrast agent dose, flip angle, and repetition time, and the resulting dual-echo rCBV was compared to standard single-echo rCBV obtained with preload (double-dose). Dual-echo rCBV was comparable to standard double-dose single-echo protocols (mean (standard deviation) tumor rCBV 2.17 (1.28) vs. 2.06 (1.20), respectively). High rCBV similarity was observed (CCC = 0.96), which was maintained across both flip angle (CCC = 0.98) and repetition time (CCC = 0.96) permutations, demonstrating that dual-echo acquisitions provide flexibility in acquisition parameters. Furthermore, a single dual-echo acquisition was shown to enable quantification of both perfusion and permeability metrics. In conclusion, single-dose dual-echo acquisitions provide similar rCBV to standard double-dose single-echo acquisitions, suggesting contrast agent dose can be reduced while providing significant pulse sequence flexibility and complementary tumor perfusion and permeability metrics.
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