期刊
FOOD CHEMISTRY
卷 196, 期 -, 页码 381-387出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2015.09.053
关键词
Chitosan; Modification; Antifungal activity; SEM; Acute toxicity
资金
- Natural Science Foundation of Zhejiang Province of China [Y3110204]
- Technology Planning Project of Zhejiang Province of China [2011C12031]
- National Science Foundation of China [21102129]
- Food Science and Engineering the most important discipline of Zhejiang province [JYTSP20142072]
Pyridine moieties were introduced into chitosan by nucleophilic substitution to afford N-(1-carboxybutyl-4-pyridinium) chitosan chloride (pyridine chitosan). The resulting chitosan derivative was well characterized, and its antifungal activity was examined, based on the inhibition of mycelial growth and spore germination. The results indicated that pyridine chitosan exhibited enhanced antifungal activity by comparison with pristine chitosan. The values of the minimum inhibitory concentration and the minimal fungicidal concentration of pyridine chitosan against Fulvia fulva were 0.13 mg/ml and 1 mg/ml, respectively, while the corresponding values against Botrytis cinerea were 0.13 mg/ml and 4 mg/ml, respectively. Severe morphological changes of pyridine chitosan-treated B. cinerea were observed, indicative that pyridine chitosan could damage and deform the structure of fungal hyphae and subsequently inhibit strain growth. Non-toxicity of pyridine chitosan was demonstrated by an acute toxicity study. These results are beneficial for assessing the potential utilization of this chitosan derivative and for exploring new functional antifungal agents with chitosan in the food industry. (C) 2015 Elsevier Ltd. All rights reserved.
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