期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 25, 期 18, 页码 8985-8996出版社
WILEY
DOI: 10.1111/jcmm.16859
关键词
autophagy; CCAT2; hepatocellular carcinoma; metastasis
资金
- Nature Science Foundation of Shandong Province [ZR2018LH014]
- National Nature Science Foundation of China [81802467]
The study found that lncRNA CCAT2 is significantly upregulated in HCC tissues, correlating with advanced stage and venous invasion. Further experiments revealed that CCAT2 induces autophagy and promotes migration and invasion in vitro and in vivo. Mechanistic investigations showed that CCAT2 regulates HCC by affecting miR-4496/Atg5 in the cytoplasm and binding with ELAVL1/HuR in the nucleus to facilitate HCC progression.
Autophagy is thought to contribute to the pathogenesis of many diseases, including cancer. Long non-coding RNA (lncRNA) CCAT2 functions as an oncogene in a variety of tumours. However, it is still unknown whether CCAT2 is involved in autophagy and metastasis of hepatocellular carcinoma (HCC). In our study, we found that lncRNA CCAT2 expression was significantly increased in HCC tissue and was correlated with advanced stage and venous invasion. Further experiments revealed that CCAT2 induced autophagy and promoted migration and invasion in vitro and in vivo. Mechanistic investigations found that CCAT2 involved in HCC by regulating miR-4496/Atg5 in cytoplasm. In nucleus, CCAT2 bound with ELAVL1/HuR to facilitate HCC progression. Our findings suggest that CCAT2 is an oncogenic factor in the progression of HCC with different regulatory mechanisms and may serve as a target for HCC therapy.
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