MICAL2 fine-tunes Arp2/3 for actin branching

Article Cell Biology

The cell pushes back: The Arp2/3 complex is a key orchestrator of cellular responses to environmental forces

Vassilis Papalazarou et al.

Summary: The Arp2/3 complex coordinates the formation of branched actin networks, which are sensitive to mechanical forces and allow cells to generate pushing forces, influencing cellular processes.

CURRENT OPINION IN CELL BIOLOGY (2021)

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Article Multidisciplinary Sciences

Propagation of F-actin disassembly via Myosin15-Mical interactions

Shannon K. Rich et al.

Summary: The study identifies a mechanism involving Myo15 and Mical that spatially and temporally positions F-actin disassembly to drive cellular breakdown and reconstruction, while also suggesting that other F-actin-trafficked-cargo may be influenced by this disassembly for directional orienting of rebuilding.

SCIENCE ADVANCES (2021)

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Article Cell Biology

MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes

Chiara Galloni et al.

Summary: The study found that Arp3 and Arp3B isocomplexes both efficiently promote actin assembly but generate branched actin networks with different disassembly rates, with Arp3B dissociating significantly faster than Arp3. This difference is due to the oxidation of Arp3B by MICAL2, which is recruited to the actin network by coronin 1C, and together with cortactin, they promote the disassembly of branched actin networks.

JOURNAL OF CELL BIOLOGY (2021)

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Article Chemistry, Multidisciplinary