4.7 Editorial Material

MICAL2 fine-tunes Arp2/3 for actin branching

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JOURNAL OF CELL BIOLOGY
卷 220, 期 8, 页码 -

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ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.202106176

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资金

  1. Canadian Institutes of Health Research [PJT169125]
  2. Natural Sciences and Engineering Research Council of Canada [RGPIN-202005388]
  3. Canada Research Chairs Program [950-231665]
  4. Cancer Research UK core grant [A17196]

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The study demonstrates that MICAL2 mediates methionine oxidation of ARP3B, disrupting ARP2/3 complexes and causing disassembly of branched actin filaments.
The ARP2/3 complex promotes branched actin networks, but the importance of specific subunit isoforms is unclear. In this issue, Galloni, Carra, et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202102043) show that MICAL2 mediates methionine oxidation of ARP3B, thus destabilizing ARP2/3 complexes and leading to disassembly of branched actin filaments.

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