期刊
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
卷 147, 期 10, 页码 2885-2892出版社
SPRINGER
DOI: 10.1007/s00432-021-03687-3
关键词
ESCC; Inflammation; HERPACC
类别
资金
- Ministry of Education, Science, Sports, Culture and Technology of Japan
- Ministry of Health, Labour and Welfare of Japan
- Uehara Memorial Foundation
- U.S. National Cancer Institute
This study examined circulating levels of inflammation- and immune-related proteins for associations with Esophageal Squamous Cell Carcinoma (ESCC). The results identified several inflammatory and immune molecules significantly associated with ESCC, suggesting the need for further replication and functional characterization.
Background Esophageal squamous cell carcinoma (ESCC) is the most common histologic subtype of esophageal cancer globally. The development of squamous cell carcinoma has important inflammatory influences and effects. We, therefore, examined circulating levels of inflammation- and immune-related proteins for associations with ESCC. Methods We used pre-treatment EDTA plasma from 80 ESCC patients (44% clinical stages I and II) and 80 cancer-free control individuals within the Hospital-based Epidemiologic Research Program at Aichi Cancer Center. Levels of 184 biomarkers were measured by high-throughput multiplexed proximity extension assays using Olink's Proseek Cell Regulation and Immuno-Oncology Panels. ESCC odds ratios (OR) per quantile (based on two to four categories) of each biomarker were calculated by unconditional logistic regression models, adjusted for age, sex, cigarette smoking and alcohol consumption. Correlations among continuous biomarker levels were assessed by Spearman's rank correlation. All statistical tests were two-sided with p values < 0.05 considered as significant. Given the exploratory nature of the study, we did not adjust for multiple comparisons. Results Seven proteins were undetectable in nearly all samples. Of the remaining 177 evaluable biomarkers, levels of cluster of differentiation 40 (CD40, per quartile OR 1.64; p trend = 0.018), syntaxin 16 (STX16, per quartile OR 1.63; p trend = 0.008), heme oxygenase 1 (per quartile OR 1.59; p trend = 0.014), and gamma-secretase activating protein (GSAP, per quartile OR 1.47; p trend = 0.036) were significantly associated with ESCC. Amongst these significant markers, levels of CD40, STX16, and GSPA were moderately correlated (Rho coefficients 0.46-0.55; p < 0.05). Conclusion Our case-control study expands the range of inflammation and immune molecules associated with ESCC. These novel findings warrant replication and functional characterization.
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