Recent advances in the epigenetics of bone metabolism

Osteoporosis is a common form of metabolic bone disease that is costly to treat and is primarily diagnosed on the basis of bone mineral density. As the influences of genetic lesions and environmental factors are increasingly studied in the pathological development of osteoporosis, regulated epigenetics are emerging as the important pathogenesis mechanisms in osteoporosis. Recently, osteoporosis genome-wide association studies and multi-omics technologies have revealed that susceptibility loci and the misregulation of epigenetic modifiers are key factors in osteoporosis. Over the past decade, extensive studies have demonstrated epigenetic mechanisms, such as DNA methylation, histone/chromatin modifications, and non-coding RNAs, as potential contributing factors in osteoporosis that affect disease initiation and progression. Herein, we review recent advances in epigenetics in osteoporosis, with a focus on exploring the underlying mechanisms and potential diagnostic/prognostic biomarker applications for osteoporosis.

Automated summary

Osteoporosis, a common metabolic bone disease, is primarily diagnosed based on bone mineral density and studies have shown that epigenetics play a significant role in its pathogenesis, involving mechanisms such as DNA methylation and histone modifications. Recent research has also revealed that susceptibility loci and misregulation of epigenetic modifiers are key factors in the development of osteoporosis.