期刊
JOURNAL OF BIOSCIENCES
卷 46, 期 2, 页码 -出版社
INDIAN ACAD SCIENCES
DOI: 10.1007/s12038-021-00164-4
关键词
Adhesion; AURKA; AURKB; Erk; growth factors
类别
资金
- Indian Council of Medical Research [35/03/2019-Nano/BMS]
Aurora kinases play distinct roles in the cell cycle, regulated by cell-matrix adhesion and growth factors. The activation of AURKB is different when cells lose adhesion and undergo re-adhesion, depending on the presence of serum growth factors. Adhesion-dependent Erk activation in re-adherent fibroblasts is controlled by a novel mechanism involving adhesion-growth factor-dependent regulation of AURKB.
Aurora kinases despite their similarity have distinct roles in the cell cycle, which is regulated by cell-matrix adhesion and growth factors. This study reveals loss of adhesion and re-adhesion to differentially regulate Aurora kinases. AURKB activation that drops on the loss of adhesion recovers on re-adhesion in serum-deprived conditions but not in the presence of serum growth factors. A rapid 30 min serum treatment of serum-deprived cells blocks the adhesion-dependent recovery of AURKB, which negatively correlates with Erk activation. AZD mediated inhibition of AURKB in serum-deprived re-adherent cells promotes Erk activation and membrane ruffling, comparable to presence of serum. These studies thus define a novel adhesion-growth factor-dependent regulation of AURKB that controls adhesion-dependent Erk activation in re-adherent fibroblasts.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据