期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 109, 期 12, 页码 2673-2684出版社
WILEY
DOI: 10.1002/jbm.a.37259
关键词
electrospun; oxygen plasma; PGS; PLA; surface modification; vascular grafts
The study created a PGS/PLA composite scaffold with plasma surface modification, exhibiting mechanical properties close to natural vessels, superhydrophilic property, good blood compatibility, and enhanced cell growth, making it a suitable candidate for vascular tissue regeneration.
Plasma surface modification is one of the new methods for improving the surface properties of the scaffold and accelerating tissue regeneration. The aim of this study was to create poly glycerol sebacate/poly lactic acid (PGS/PLA) composite scaffold by electrospun method and modified the scaffold by oxygen plasma for use as a vascular graft. Plasma surface modified PGS/PLA scaffold morphology study showed relatively uniform fibers with an average diameter of 637 +/- 149.4 nm and porosity of 82%. The mechanical evaluation of the PGS/PLA scaffold showed properties close to the natural vessels. Atomic force microscopy images exhibited an increase in the roughness of the scaffold after plasma surface modification; however, hemocompatibility studies revealed that it had no adverse effect on blood compatibility. Wettability studies revealed the superhydrophilic property of the modified scaffold (contact angle near to zero). Besides, the human umbilical vein endothelial cells proliferation and adhesion were improved significantly. Obtaining mechanical properties near to the natural vessels due to the suitable composition and significant improvement in blood compatibility and cell growth make the modified PGS/PLA composite a suitable candidate for vascular tissue regeneration.
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