Fracture behavior of human cortical bone: Role of advanced glycation end-products and microstructural features

Diabetes is associated with increased fracture risk in human bone, especially in the elderly population. In the present study, we investigate how simulated advanced glycation end-products (AGEs) and materials heterogeneity affect crack growth trajectory in human cortical bone. We used a phase field fracture framework on 2D models of cortical microstructure created from human tibias to analyze crack propagation. The increased AGEs level results in a higher rate of crack formation. The simulations also indicate that the mismatch between the fracture properties (e.g., critical energy release rate) of osteons and interstitial tissue can alter the post-yielding behavior. The results show that if the critical energy release rate of cement lines is lower than that of osteons and the surrounding interstitial matrix, cracks can be arrested by cement lines. Additionally, activation of toughening mechanisms such as crack merging and branching depends on bone microstructural morphology (i.e., osteons geometrical parameters, canals, and lacunae porosities). In conclusion, the present findings suggest that materials heterogeneity of microstructural features and the crack-microstructure interactions can play important roles in bone fragility.

Automated summary

Diabetes increases fracture risk in human bone, and this study investigates the impact of simulated AGEs and materials heterogeneity on crack growth in cortical bone. Results show that AGEs level affects crack formation rate, and mismatch in fracture properties can alter post-yielding behavior, with cement lines capable of stopping crack propagation. Additionally, bone microstructural features influence toughening mechanisms such as crack merging and branching.