期刊
JOURNAL OF BIOLOGICAL PHYSICS
卷 47, 期 2, 页码 171-190出版社
SPRINGER
DOI: 10.1007/s10867-021-09572-x
关键词
Pressure gradient; Aortic coarctation; Stenosis model; Poiseuille loss; Bernoulli loss; Entrance effect
类别
资金
- European Community [224495]
Non-invasive estimation of pressure gradient in cardiovascular stenosis is crucial for assisting diagnosis and treatment. Through a systematic comparison, one of the improved models proposed in this research demonstrates the best prediction accuracy among the models studied.
Non-invasive estimation of the pressure gradient in cardiovascular stenosis has much clinical importance in assisting the diagnosis and treatment of stenotic diseases. In this research, a systematic comparison is conducted to investigate the accuracy of a group of stenosis models against the MRI- and catheter-measured patient data under the aortic coarctation condition. Eight analytical stenosis models, including six from the literature and two proposed in this study, are investigated to examine their prediction accuracy against the clinical data. The two improved models proposed in this study consider comprehensively the Poiseuille loss, the Bernoulli loss in its exact form, and the entrance effect, of the blood flow. Comparison of the results shows that one of the proposed models demonstrates a cycle-averaged mean prediction error of -0.15 +/- 3.03 mmHg, a peak-to-peak prediction error of -1.8 +/- 6.89 mmHg, which is the best among the models studied.
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