4.6 Editorial Material

An online gathering about the latest on molecular membrane biology

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Article Biochemistry & Molecular Biology

WNK1 is an assembly factor for the human ER membrane protein complex

Tino Pleiner et al.

Summary: The assembly of nascent proteins into multi-subunit complexes is regulated by WNK1, which stabilizes EMC2 and promotes assembly of EMC, playing a key role in cellular homeostasis. Depletion of WNK1 destabilizes both EMC and its membrane protein clients.

MOLECULAR CELL (2021)

Article Biochemistry & Molecular Biology

Cryo-EM structure of metazoan TRAPPIII, the multi-subunit complex that activates the GTPase Rab1

Antonio Galindo et al.

Summary: TRAPP complexes, which are nucleotide exchange factors, play vital roles in membrane traffic and autophagy. TRAPPII activates Rab11, while TRAPPIII activates Rab1, with shared core subunits affecting nucleotide exchange and specific large subunits essential for in vivo activity. Cryo-EM structures reveal the assembly of TRAPPIII complex, showing how TRAPPIII-specific subunits hold the catalytic core and large arms determine specificity. The lower resolution structure of TRAPPII suggests evolution from a single ur-TRAPP.

EMBO JOURNAL (2021)

Article Multidisciplinary Sciences

Structural basis for membrane insertion by the human ER membrane protein complex

Tino Pleiner et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Anisotropic ESCRT-III architecture governs helical membrane tube formation

Joachim Moser von Filseck et al.

NATURE COMMUNICATIONS (2020)

Article Cell Biology

Combinatorial multivalent interactions drive cooperative assembly of the COPII coat

Viktoriya G. Stancheva et al.

JOURNAL OF CELL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits

Florian Wilfling et al.

MOLECULAR CELL (2020)