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Daniel J. Elsner et al.
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Brady D. Goulden et al.
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Yasset Perez-Riverol et al.
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Iva Lucic et al.
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Nazma Malik et al.
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Yuanzhong Wang et al.
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Ruzica Bago et al.
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Jean-Marc Lapierre et al.
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Novel Features of DAG-Activated PKC Isozymes Reveal a Conserved 3-D Architecture
Iva Lucic et al.
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Shaoyong Lu et al.
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Laura Braccini et al.
NATURE COMMUNICATIONS (2015)
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Miriam Martini et al.
ANNALS OF MEDICINE (2014)
Characterization of IIPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class Ill phosphoinositide 3-kinase
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Christopher S. Theile et al.
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High-Resolution Comparative Modeling with RosettaCM
Yifan Song et al.
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Crystal Structure and Allosteric Activation of Protein Kinase C βII
Thomas A. Leonard et al.
CELL (2011)
Regulation of protein kinases by lipids
Thomas A. Leonard et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2011)
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Tung O. Chan et al.
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mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
Won Jun Oh et al.
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Wen-I Wu et al.
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Christina Gewinner et al.
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Krishna M. Vasudevan et al.
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Wei Chen et al.
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The regulation and function of Class III PI3Ks: novel roles for Vps34
Jonathan M. Backer
BIOCHEMICAL JOURNAL (2008)
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Romina Marone et al.
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Annette Schenck et al.
CELL (2008)
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
Tsuneo Ikenoue et al.
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The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
Valeria Facchinetti et al.
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MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
Juergen Cox et al.
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NH2 terminus of serum and glucocorticoid-regulated kinase 1 binds to phosphoinositides and is essential for isoform-specific physiological functions
Alan C. Pao et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2007)
Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation
Camilla Hauge et al.
EMBO JOURNAL (2007)
Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips
Juri Rappsilber et al.
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(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms
Florian Lang et al.
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A time- and cost-efficient system for high-level protein production in mammalian cells
A. Radu Aricescu et al.
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CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4
Thomas Slagsvold et al.
EMBO JOURNAL (2006)
Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3
Maude Tessier et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Assay of protein kinases using radiolabeled ATP: a protocol
C. James Hastie et al.
NATURE PROTOCOLS (2006)
Coincidence detection in phosphoinositide signaling
JG Carlton et al.
TRENDS IN CELL BIOLOGY (2005)
The type Iα inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane
I Ivetac et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Identification of different specificity requirements between SGK1 and PKBα
JT Murray et al.
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Structural basis of membrane targeting by the phox homology domain of cytokine-independent survival kinase (CISK-PX)
Y Xing et al.
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Phosphosite: A bioinformatics resource dedicated to physiological protein phosphorylation
PV Hornbeck et al.
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The protein kinase complement of the human genome
G Manning et al.
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Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3β) at serine-9 through direct interaction
FY Dai et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Activation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphate
JV Virbasius et al.
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Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)
A Brunet et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Identification of CISK, a new member of the SGK kinase family that promotes IL-3-dependent survival
D Liu et al.
CURRENT BIOLOGY (2000)
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