4.6 Editorial Material

Shining light on location-biased cAMP signaling

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JOURNAL OF BIOLOGICAL CHEMISTRY
卷 297, 期 3, 页码 -

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ELSEVIER
DOI: 10.1016/j.jbc.2021.101118

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  1. US National Institutes of Health (NIH) [R01-DK111427, R01-DK116780]

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The study demonstrates the significant impact of localized cAMP production on cellular functions, particularly in phospho-responses, as revealed through phospho-proteomic analysis.
cAMP is the indispensable second messenger regulating cell metabolism and function in response to extracellular hormones and neurotransmitters. cAMP is produced via the activation of G protein-coupled receptors located at both the cell surface and inside the cell. Recently, Tsvetanova et al. explored cAMP generation in distinct locations and the impact on respective cell functions. Using a phospho-proteomic analysis, they provide insight into the unique role of localized cAMP production in cellular phospho-responses.

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