The Gut-Lung Axis in Cystic Fibrosis

Cystic fibrosis (CF) is a heritable, multiorgan disease that impacts all tissues that normally express cystic fibrosis transmembrane conductance regulator (CFTR) protein. While the importance of the airway microbiota has long been recognized, the intestinal microbiota has only recently been recognized as an important player in both intestinal and lung health outcomes for persons with CF (pwCF). Here, we summarize current literature related to the gut-lung axis in CF, with a particular focus on three key ideas: (i) mechanisms through which microbes influence the gut-lung axis, (ii) drivers of microbiota alterations, and (iii) the potential for intestinal microbiota remediation.

Automated summary

Cystic fibrosis is a heritable multiorgan disease that affects tissues expressing the CFTR protein. Recent research has highlighted the crucial role of intestinal microbiota in the gut-lung axis for individuals with CF. Current literature focuses on understanding microbial influences, drivers of microbiota alterations, and the potential for intestinal microbiota remediation in the context of CF.