期刊
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
卷 38, 期 11, 页码 3005-3013出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10815-021-02301-2
关键词
Male infertility; Infertility; Antioxidants; Selenium; Zinc; Vitamin E; Semen parameters; Sperm DNA fragmentation; Plasma levels
资金
- Eunice Kennedy Shriver National Institute for Children Health and Development, National Institutes of Health [K23 HD097307]
- CREST Program [R25 HD075737]
- National Institutes of Health (NIH)/Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) [U10HD077844, U10HD077680, 1U10 HD077841, U10HD027049, U10HD038992, U10HD039005, U10HD055925]
In the USA, among men attending fertility centers with sufficient plasma antioxidant levels of zinc, selenium, or vitamin E, no association was observed between vitamins and semen parameters or clinical outcomes in couples with male infertility. Higher levels of antioxidants among men with circulating antioxidants in the normal range do not appear to confer benefit on semen parameters or male fertility.
Purpose The understanding of the role of plasma antioxidant levels in male fertility in the USA is limited. In a secondary analysis of the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial, we sought to determine whether serum levels of vitamin E (alpha-tocopherol), zinc, and selenium were correlated with semen parameters and couple fertility outcomes. Methods This study is a secondary analysis of the MOXI clinical trial. The primary endpoints in this secondary analysis include semen parameters, and DNA fragmentation and clinical outcomes including pregnancy and live birth. Analyses were completed using Wilcoxon's rank-sum test and linear regression models. Results At baseline, the analysis included plasma labs for vitamin E (n = 131), selenium (n = 124), and zinc (n = 128). All baseline plasma values were in the normal ranges. There was no association between selenium, zinc, or vitamin E levels and semen parameters or DNA fragmentation. Baseline antioxidant levels in the male partners did not predict pregnancy or live birth among all couples. Among those randomized to placebo, baseline male antioxidant levels did not differ between those couples with live birth and those that did not conceive or have a live birth. Conclusions Among men attending fertility centers in the USA, who have sufficient plasma antioxidant levels of zinc, selenium, or vitamin E, no association was observed between vitamins and semen parameters or clinical outcomes in couples with male infertility. Higher levels of antioxidants among men with circulating antioxidants in the normal range do not appear to confer benefit on semen parameters or male fertility.
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