期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 24, 期 4, 页码 344-352出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2021.1933959
关键词
Piperaceae; Piper wallichii; piwalkanone; piwallidione; piperine; antibacterial activity
资金
- Thailand Research Fund via Direct Basic Research Grant [DBG6180092]
A phytochemical investigation of the stems and leaves of Piper wallichii led to the isolation of two new compounds, piwalkanone and piwallidione, along with nine known compounds. Compounds 2 and 3 showed inhibitory activities against pathogenic bacteria.
A phytochemical investigation of the stems and leaves of Piper wallichii led to the isolation of two new compounds, an aryl alkanone, piwalkanone (1) and a dioxoaporphine alkaloid, piwallidione (2), together with nine known compounds, a dioxoaporphine alkaloid, cepharadione A (3); two aristolactams, piperolactam A (4) and stigmalactam (5); a piperidine, piperine (6); four isobutylamides, piperlonguminine (7), pellitorine (8), N-isobutyl-2E,4E-octadecadienamide (9), and guineensine (10); and a tyramine, N-trans-feruloyltyramine (11). Their structures were elucidated on the basis of spectroscopic evidence (IR, H-1 NMR, C-13 NMR and 2 D NMR) and MS. Compounds 2 and 3 showed inhibitory activities against pathogenic bacteria, Bacillus cereus, Bacillus subtilis and Staphylococcus aureus.
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