期刊
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
卷 76, 期 12, 页码 3144-3150出版社
OXFORD UNIV PRESS
DOI: 10.1093/jac/dkab310
关键词
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资金
- Antimicrobial Resistance Cross Council Initiative [NE/N01961X/1, MR/S004769/1, BB/T004592/1]
- Medical Research Council [MR/T005408/1]
- National Institute for Health Research
The study found limited impact of FQ-R E. coli from dairy farms on community bacteriuria in the local human population. Reducing fluoroquinolone use may lower the prevalence of FQ-R E. coli on farms, especially when dry cow therapy targets resistant E. coli ecology.
Background: Our primary aim was to test whether cattle-associated fluoroquinolone-resistant (FQ-R) Escherichia coli found on dairy farms are closely phylogenetically related to those causing bacteriuria in humans living in the same 50x50km geographical region suggestive of farm-human sharing. Another aim was to identify risk factors for the presence of FQ-R E. coli on dairy farms. Methods: FQ-R E. coli were isolated during 2017-18 from 42 dairy farms and from community urine samples. Forty-two cattle and 489 human urinary isolates were subjected to WGS, allowing phylogenetic comparisons. Risk factors were identified using a Bayesian regularization approach. Results: Of 489 FQ-R human isolates, 255 were also third-generation-cephalosporin-resistant, with strong genetic linkage between aac(6')Ib-cr and bla(CTX-M-15). We identified possible farm-human sharing for pairs of ST744 and ST162 isolates, but minimal core genome SNP distances were larger between farm-human pairs of ST744 and ST162 isolates (71 and 63 SNPs, respectively) than between pairs of isolates from different farms (7 and 3 SNPs, respectively). Total farm fluoroquinolone use showed a positive association with the odds of isolating FQ-R E. coli, while total dry cow therapy use showed a negative association. Conclusions: This work suggests that FQ-R E. coli found on dairy farms have a limited impact on community bacteriuria within the local human population. Reducing fluoroquinolone use may reduce the on-farm prevalence of FQ-R E. coli and this reduction may be greater when dry cow therapy is targeted to the ecology of resistant E. coli on the farm.
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