4.5 Review

Natural products targeting cancer cell dependency

期刊

JOURNAL OF ANTIBIOTICS
卷 74, 期 10, 页码 677-686

出版社

SPRINGERNATURE
DOI: 10.1038/s41429-021-00438-x

关键词

-

资金

  1. Science and Technology Development Fund, Macau SAR [FDCT/0107/2020/A1, FDCT/0030/2020/A]
  2. University of Macau [MYRG2019-00116-FHS, MYRG2020-00229-FHS]

向作者/读者索取更多资源

Precision cancer medicine targets defective tumor suppressors through synthetic lethality, which has shown promising results in clinical settings. Large-scale screenings and the discovery of natural products play important roles in identifying synthetic lethal partners of tumor suppressors.
Precision cancer medicine is a tailored treatment approach for individual cancer patients with different genomic characteristics. Mutated or hyperactive oncogenes have served as main drug targets in current precision cancer medicine, while defective or inactivated tumor suppressors in general have not been considered as druggable targets. Synthetic lethality is one of very few approaches that enable to target defective tumor suppressors with pharmacological agents. Synthetic lethality exploits cancer cell dependency on a protein or pathway, which arises when the function of a tumor suppressor is defective. This approach has been proven to be effective in clinical settings since the successful clinical introduction of BRCA-PARP synthetic lethality for the treatment of breast and ovarian cancer with defective BRCA. Subsequently, large-scale screenings with RNAi, CRISPR/Cas9-sgRNAs, and chemical libraries have been applied to identify synthetic lethal partners of tumor suppressors. Natural products are an important source for the discovery of pharmacologically active small molecules. However, little effort has been made in the discovery of synthetic lethal small molecules from natural products. This review introduces recent advances in the discovery of natural products targeting cancer cell dependency and discusses potentials of natural products in the precision cancer medicine.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据