期刊
JOURNAL OF ANTIBIOTICS
卷 74, 期 8, 页码 485-495出版社
SPRINGERNATURE
DOI: 10.1038/s41429-021-00429-y
关键词
-
资金
- JSPS KAKENHI [JP17H06412, JP20K05858]
Six new 11-mer peptaibols named zealpeptaibolins, A - F, were isolated from soil fungus Trichoderma sp. RK10-F026, showing that peptaibol production is dependent on culture conditions. Among these, zealpeptaibolin F exhibited the highest cytotoxicity against K562 leukemia cells.
Six new 11-mer peptaibols designed as zealpeptaibolins, A - F were isolated from the soil fungus, Trichoderma sp. RK10-F026, based on the principal component analysis of the MS data from five different culture compositions. Previously, 20-mer peptaibols from the same fungal strain were identified; 11-mer peptaibols in contrast were discovered from a different culture condition, signifying peptaibol production was culture condition-dependent. These peptaibols contained three Aib-Pro motifs in the sequence. The structures were established by NMR and HR-MS experiments including detailed MS/MS fragmentations. The absolute configurations were determined by Marfey's analysis. Zealpeptaibolin F exhibited the strongest cytotoxicity toward K562 leukemia cells with an IC50 value of 0.91 mu M.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据