期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 82, 期 4, 页码 1461-1466出版社
IOS PRESS
DOI: 10.3233/JAD-210331
关键词
Clinical trial; dementia; dementia risk score; lifestyle intervention; prevention
资金
- European Research Council [804371]
- Academy of Finland [287490, 294061, 319318, 317465]
- Finnish Cultural Foundation
- Yrjo Jahnsson Foundation (Finland)
- Alzheimerfonden
- Region Stockholm ALF (Sweden)
- Oulu University Hospital
- Oulu City Hospital (Finland)
- EU 7th framework collaborative project grant (HATICE)
- EU Joint Programme -Neurodegenerative Disease Research (MIND-AD)
- UEF Strategic funding for UEFBRAIN (Finland)
- Kuopio University Hospital (Finland)
- Finnish Social Insurance Institution
- Finnish Ministry of Education and Culture
- Juho Vainio Foundation (Finland)
- Alzheimer's Research and Prevention Foundation (US)
- Alzheimerfonden (Sweden)
- Swedish Research Council
- Center for Innovative Medicine (CIMED) at Karolinska Institutet
- Region Stockholm (ALF, NSV)
- Knut and Alice Wallenberg Foundation (Sweden)
- Stiftelsen Stockholms sjukhem (Sweden)
- Konung Gustaf V:s och Drottning Victorias Frimurarstiftelse (Sweden)
- EU Joint Programme -Neurodegenerative Disease Research (EURO-FINGERS)
- Juho Vainio Foundation
- Jalmari and Rauha Ahokas Foundation, Finland
- Academy of Finland (AKA) [319318, 319318] Funding Source: Academy of Finland (AKA)
The study demonstrates that a multidomain lifestyle intervention can reduce the risk of cognitive impairment in older adults, indicating the preventive potential of the intervention.
We investigated the effect of a multidomain lifestyle intervention on the risk of dementia estimated using the validated CAIDE risk score (post-hoc analysis). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a 2-year randomized controlled trial among 1,260 at-risk older adults (60-77 years). Difference in the estimated mean change in CAIDE score at 2 years in the intervention compared to the control group was -0.16 (95 % CI -0.31 to 0.00) (p = 0.013), corresponding to a relative dementia risk reduction between 6.04-6.50%. This could be interpreted as a reflection of the prevention potential of the intervention.
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