期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 147, 期 6, 页码 1983-1996出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2021.03.035
关键词
Airway smooth muscle; airway remodeling; asthma; deep inspiration; inflammation; bronchodilation; bronchoconstric-tion; bronchial thermoplasty; genetics; epigenetics; bitter taste re-ceptors; olfactory receptors
Airway smooth muscle (ASM) cells play a central role in the pathogenesis of asthma, controlling muscle tone and participating in airway hyperresponsiveness and inflammation. Therapeutic approaches for asthma require a comprehensive understanding of ASM structure and function.
The airway smooth muscle (ASM) cell plays a central role in the pathogenesis of asthma and constitutes an important target for treatment. These cells control muscle tone and thus regulate the opening of the airway lumen and air passage. Evidence indicates that ASM cells participate in the airway hyperresponsiveness as well as the inflammatory and remodeling processes observed in asthmatic subjects. Therapeutic approaches require a comprehensive understanding of the structure and function of the ASM in both the normal and disease states. This review updates current knowledge about ASM and its effects on airway narrowing, remodeling, and inflammation in asthma. (J Allergy Clin Immunol 2021;147:1983-95.)
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